Cardiac Resynchronization in Mildly Symptomatic Heart Failure and Asymptomatic Patients

Cardiac resynchronization therapy in asymptomatic and mildly symptomatic chronic systolic heart failure: a new era of systolic heart failure management?

T he incidence and prevalence of heart failure syndrome continue to increase, and it therefore remains a significant health problem in developed western countries. It is accompanied by high morbidity and mortality, and significantly affects the burden on health care system as well as the patients’ quality of life. Cardiac resynchronization therapy (CRT) with biventricular stimulation has recent...

Brain natriuretic peptide and cardiac resynchronization therapy in patients with mildly symptomatic heart failure.

BACKGROUND There are limited data on the prognostic implications of brain natriuretic peptide (BNP) assessment in patients with mildly symptomatic heart failure (HF) who receive cardiac resynchronization therapy with a defibrillator (CRT-D). METHODS AND RESULTS The effect of elevated baseline and 1-year BNP levels (dichotomized at the upper tertile BNP of 120 pg/mL) on the risk of HF or death...

Systematic review: cardiac resynchronization in patients with symptomatic heart failure.

BACKGROUND Even with optimal pharmacotherapy, symptomatic heart failure is associated with substantial morbidity and mortality. PURPOSE To determine the efficacy and safety of cardiac resynchronization therapy in adults with advanced systolic heart failure. DATA SOURCES The Cochrane Central Register of Controlled Trials (2002, volume 4), MEDLINE (1980-2003), EMBASE (1980-2003), other electr...

Cardiac resynchronization therapy in asymptomatic or mildly symptomatic heart failure patients in relation to etiology: results from the REVERSE (REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction) study.

OBJECTIVES The purpose of this study was to determine the effects of cardiac resynchronization therapy (CRT) with respect to heart failure etiology among patients in the REVERSE (REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction) study. BACKGROUND CRT improves outcomes in New York Heart Association functional class III/IV heart failure with wide QRS with a more pr...

Is it time to expand the use of cardiac resynchronization therapy to patients with mildly symptomatic heart failure?